A car bomb strikes the Egyptian capital's police headquarters before two smaller blasts are detonated on the third anniversary of uprising against Hosni Mubarak.<br /><br />A car bomb struck the main Egyptian police headquarters on Friday in the heart of Cairo, killing at least four people in a hugely symbolic attack on the eve of the third anniversary of the 2011 uprising that toppled longtime autocratic ruler Hosni Mubarak. <br /><br />The blast shook and damaged nearby buildings, including a museum and courthouse, and sent black smoke rising above the Egyptian capital as a large number of ambulances rushed to the scene. <br /><br />No one immediately claimed responsibility for the 6:30 a.m. blast, but Egypt has seen a sharp rise in Islamic militant attacks targeting police and the military in the aftermath of the July 3 coup that ousted Islamist President Mohammed Morsi. Immediately after the blast, local residents gathered and chanted against Morsi's Muslim Brotherhood. <br /><br />The Health Ministry said in a statement that four people were killed and nearly 50 wounded. <br /><br />Hours after the attack, a crude explosive device killed one policeman and wounded nine others in another Cairo neighbourhood, the Interior Ministry said in a statement. <br /><br />A loud blast was also heard in the Talbeya neighbourhood in Giza, a large district on the outskirts of Cairo, witnesses told Reuters. There were no immediate reports of casualties. <br /><br /><br />Get the latest headlines http://www.telegraph.co.uk/<br /><br />Subscribe to The Telegraph http://www.youtube.com/subscription_center?add_user=telegraphtv<br /><br />Like us on Facebook http://www.facebook.com/telegraph.co.uk<br />Follow us on Twitter https://twitter.com/telegraph<br />Follow us on Google+ https://plus.google.com/102891355072777008500/<br /><br />Telegraph.co.uk and YouTube.com/TelegraphTV are websites of The Daily Telegraph, the UK's best-selling quality daily newspaper providing news and analysis on UK and world events, business, sport, lifestyle and culture.