The San Francisco Giants will continue their interleague series against the Chicago White Sox in a Major League Baseball betting pick prediction Wednesday afternoon. <br /> <br />Start time from Chicago is set for 2PM Eastern Time with national television coverage provided by the MLB Extra Innings channel. <br /> <br />The MLB odds from this contest have the home side Chicago White Sox favored by -125 odds with the take back on the road underdog San Francisco Giants at +105 odds. The run total is lined at seven runs.