Negotiating the nuclear agreement was a torturous, two-year process for Iran's leaders, but a new kind of struggle is unfolding now in Iran, where the supreme leader, Ayatollah Ali Khamenei, and President Hassan Rouhani have begun to tackle a question Iranians have not thought about much since the revolution 37 years ago: How to deal with their great enemy, the United States, after having reached a compromise with it.<br />"We have announced that we will not negotiate with the Americans on any issue other than the nuclear case," Mr. Khamenei said this month.<br />Speaking to a group of hard-line students recently he was even more explicit, telling them to "prepare for the continuation of the fight against America."<br />By contrast, Mr. Rouhani said on Sunday that the nuclear agreement was "not the end of the way," but "a beginning for creating an atmosphere of friendship and cooperation with various countries."