The S&P 500 index showed five new 52-week highs and three new lows, while the Nasdaq recorded 11 new highs and 16 new lows.<br />The S&P 500 healthcare index plunged 0.91 percent, setting it up for its worst day since Jan.<br />11, when Trump said drugmakers were "getting away with murder" by charging high prices.<br />ET (1435 GMT), the Dow was down 28.62 points, or 0.14 percent, at 20,925.72, the S&P 500 was down 4.79 points, or 0.20 percent, at 2,370.52<br />and the Nasdaq Composite was down 7.35 points, or 0.13 percent, at 5,841.82.<br />Newly minted shares of Snapchat owner Snap Inc fell 8.5 percent to $21.70 after a group representing large institutional investors asked stock index providers to bar the company<br />and others who sell non-voting shares from their stock benchmarks.<br />Johnson & Johnson was the top drag on the S&P 500 and the Dow Jones Industrial Average, while Amgen had a similar influence on the Nasdaq.<br />The Federal Reserve has left no stone unturned in preparing the markets for tighter monetary policy, with an unusual number<br />of key officials including Fed Chair Janet Yellen hinting at a rate hike in the central bank’s March 14-15 meeting.<br />(Reuters) - Healthcare stocks took a hammering on Tuesday, dragging the major U. S.<br />indexes lower, after President Donald Trump tweeted about lowering drug prices.<br />Nine of the other 11 major S&P sectors marked slight losses as investors position themselves for an interest rate hike next week.<br />The healthcare selloff could lead to the first back-to-back losses for the S&P 500 and the Dow in more than one month.