<br /> A federal appeals court upheld the conviction and seven-year prison term of Martin Shkreli.<br />Shkreli is the pharmaceutical executive known as “Pharma Bro.”<br />Shkreli defrauded investors in his hedge funds.<br />He also conspired to manipulate the stock of Retrophin Inc, a biotechnology company he ran.<br />The decision closes one of the last legal avenues for him to regain his freedom and quickly reenter the public eye. <br />