What Happens to Your Health <br />When You Lose Your Job? Losing a job can be one of the most stressful events you can experience in your life. But how does it affect your health? Lisa Orbé-Austin, psychologist One major symptom is disrupted sleep, <br />insomnia or sleeping too much. Depression is also common, as 356,000 Americans report having depression after losing a job. Mood changes, such as a decrease in agreeableness, may happen if you are unemployed long-term. Your body's fight-or-flight response may be activated, giving you headaches and an upset stomach. Keeping track of your goals and achievements can help combat these changes. Sticking to a routine and building structure to your day can also help <br />you cope with stress.