<p>Kharkiv region head Oleg Synegubov said on Tuesday that Russian missile attacks hit the centre of Ukraine's second-largest city, including residential areas and the regional administration building, as Moscow started day six of its invasion.</p><p><br>Synegubov said Russia launched GRAD and cruise missiles on Kharkiv but that the city defence was holding.</p><p><br>Wearing a flak jacket and a helmet, Synegubov said in a video posted on social media on Tuesday morning that it was too early to know the number of casualties.</p><p><br>He shared a video showing Kharkiv regional administration building being hit by a missile and exploding. Reuters verified the authenticity of the video.</p>