According to a recent study, a group of Wake Forest University School of Medicine researchers found a new way of treating solid tumours with the creation of a novel nanoparticle. <br /><br />They also discovered that cancers of breast, colon, head and neck have tumours that are solid. <br /><br />In the study, associate professor of cancer biology at Wake Forest University School of Medicine, Dr Xin Ming and his team used a nanoparticle to deliver a small molecule called ARL67156 to promote an anti-tumour immune response in mouse models of colon, head and neck, and metastatic breast cancer, resulting in increased survival. <br /><br />The study was published online in a journal called Science Translational Medicine. <br /><br />Although Immunotherapy has transformed cancer treatment, only about 20 per cent of patients respond to treatment. The presence of adenosine in the tumour microenvironments can lead to a poor therapeutic response. However, the nanoparticle's design does allow the accumulation and release of ARL67156 selectively in solid tumours. <br /><br />Concluding the research, Ming said, “Our study suggests there’s a potential translation of our nanoparticle therapeutics for treating human cancers and that it might also boost the effectiveness of existing treatments. These findings warrant further evaluation.”<br />
