Uploaded with permission from original creator AronRa. http://www.youtube.com/aronra<br /><br />Regarding side-effects of high-density LRP5 function: Many subjects do experience detrimental side-effects, and sometimes these can be severe, but this is not the case with all subjects, some of which suffer no down-side to unbreakable bones.<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180253/<br />http://www.nejm.org/doi/full/10.1056/NEJM200405133502017<br /><br />Regarding the Tibetan mutations against Hyplexia:<br />http://www.ncbi.nlm.nih.gov/pubmed/21030426<br /><br />"The strongest signal of natural selection came from endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1), a transcription factor involved in response to hypoxia. One single-nucleotide polymorphism (SNP) at EPAS1 shows a 78% frequency difference between Tibetan and Han samples, representing the fastest allele frequency change observed at any human gene to date."<br />http://www.ncbi.nlm.nih.gov/pubmed/20595611<br /><br />http://darwinwasright.homestead.com/8thFFoC.html
